Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Synthesis of Highly Functionalized Indoles and Indolones via Selectivity-Switchable Olefinations

Synthesis of Highly Functionalized Indoles and Indolones via Selectivity-Switchable Olefinations
Zu-Feng Xiao, Ting-Hui Ding, Yan-Biao Kang, Jian-Ping Qu
Highly functionalized indoles and indolones were prepared via selectivity-switchable mono- or diolefinations. The Julia olefination of the products followed by a Brønsted acid-prompted cyclization afforded indolones, whereas the indoles were obtained by a sequential Wittig olefination and electrocyclization. This method opens divergent access to highly functionalized nitrogen-containing bicyclic or tricyclic heterocycles.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b03158

DOI: 10.1021/acs.joc.7b03158

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.