3 years ago

Manganese(I)-Catalyzed C–H 3,3-Difluoroallylation of Pyridones and Indoles

Manganese(I)-Catalyzed C–H 3,3-Difluoroallylation of Pyridones and Indoles
Ao Zhang, Jiabin Ni, Hongchuan Zhao
A novel and efficient C–H activation approach for the direct 3,3-difluoroallylation of 2-pyridones and indoles is herein reported using a manganese(I) complex as the catalyst. A broad range of substrates with diverse functional groups were tolerated. Moreover, late-stage C–H functionalization of bioactive molecules was achieved in good yield.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01282

DOI: 10.1021/acs.orglett.7b01282

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