Cancer
Cancer
5 years ago

PD-1/PD-L1 Axis in Lung Cancer

Hellmann, Matthew D., Santini, Fernando C.
Cancer immunotherapies have revolutionized the treatment of non–small cell lung cancer. Yet, only a small subset of patients will benefit from PD-1 or PD-L1 blockade. PD-L1 tumor cell expression is the only approved biomarker at present. Tumor mutational burden and other emerging biomarkers should improve patient selection. Combination therapy approaches with chemotherapy or cytotoxic T-lymphocyte-associated protein 4 blockade may increase the proportion of patients who benefit from immunotherapy. Although use of immunotherapy in lung cancers with targetable oncogenes has not been particularly successful, the benefit of PD-(L)1 inhibitors in early-stage disease is emerging. This review briefly describes the evolution of the clinical development and future directions of PD-(L)1 blockade in patients with lung cancers.

Publisher URL: https://journals.lww.com/journalppo/Fulltext/2018/01000/PD_1_PD_L1_Axis_in_Lung_Cancer.4.aspx

DOI: 10.1097/PPO.0000000000000300

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