Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages

Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
Younghoon Kim, Kyung Lock Kim, Md Rumum Rohman, Eun Hui Lee, Bahiru Punja Benke, Soonsang Hong, In-Chul Hwang, Kimoon Kim, Pulakesh Aich, Joon Ho Roh
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b02708

DOI: 10.1021/jacs.7b02708

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.