5 years ago

Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages

Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
Younghoon Kim, Kyung Lock Kim, Md Rumum Rohman, Eun Hui Lee, Bahiru Punja Benke, Soonsang Hong, In-Chul Hwang, Kimoon Kim, Pulakesh Aich, Joon Ho Roh
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a living cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b02708

DOI: 10.1021/jacs.7b02708

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