Biochimica et Biophysica Acta - Biomembranes
Biochimica et Biophysica Acta - Biomembranes
5 years ago

Differential binding of the HIV-1 envelope to phosphatidylserine receptors

Differential binding of the HIV-1 envelope to phosphatidylserine receptors
Prior work has shown that the HIV-1 envelope of the human immunodeficiency virus (HIV) interacts directly with T-cell immunoglobulin mucin (TIM) family proteins. Herein, we demonstrate that HIV-1 envelope glycoproteins from varying HIV-1 clades bind differentially to TIM proteins and functionally similar proteins acting as phosphatidylserine (PtdSer) receptors. Using enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR) technology, we show that lysate containing HIV-1 envelope and recombinant HIV-1 envelope glycoproteins bind TIM-4 and advanced glycosylation end product-specific receptor (AGER). The complex binding of HIV-1 UG21 gp140 to TIM-4 or AGER suggests a biphasic interaction with these proteins.

Publisher URL: www.sciencedirect.com/science

DOI: S0005273617301888

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