3 years ago

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin
Michaela Hejl, Andrea Bileck, Petra Heffeter, Dominique Kreutz, Christian G. Hartinger, Bernhard K. Keppler, Tamara Weiss, Lilli Winter, Samir Jana, Annesha Chatterjee, Arindam Bhattacharyya, Michael A. Jakupec, Walter Berger, Klaudia Cseh, Gerhard Wiche, Beatrix Alte, Christopher Gerner, Samuel M. Meier, Matthias H. M. Klose, Johanna C. Mader
Metal-based anticancer agents are often designed as prodrugs with supposedly low selectivity. In contrast to this approach, in their Communication (http://doi.org/10.1002/anie.201702242), S. M. Meier, C. Gerner, and co-workers describe an unexpected target selectivity of an organometallic ruthenium(II) complex, obtained by a combination of proteomics-based methods, termed target-response profiling. Plectin was identified as the main cellular target. Plectin-targeting interferes with the microtubule network and thus may be harnessed as an anticancer strategy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201704644

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