3 years ago

Catalytic Enantioselective Synthesis of 2,5-Dihydrooxepines

Catalytic Enantioselective Synthesis of 2,5-Dihydrooxepines
Do Hyun Ryu, Soo Min Cho, Su Yong Shim, Anipireddy Venkateswarlu
Cyclopropanes possessing formyl and vinyl groups are converted into 2,5-dihydrooxepines with release of the angle strain through a boat-like transition state. In their Communication (DOI: 10.1002/anie.201700890), D. H. Ryu and co-workers show that a catalytic tandem cyclopropanation/retro-Claisen rearrangement reaction in the presence of a chiral oxazaborolidinium ion catalyst gives highly functionalized 2,5-dihydrooxepines in a single step with excellent enantioselectivity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201704987

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.