3 years ago

Achiral Pyridine Ligand-Enabled Enantioselective Radical Oxytrifluoromethylation of Alkenes with Alcohols

Achiral Pyridine Ligand-Enabled Enantioselective Radical Oxytrifluoromethylation of Alkenes with Alcohols
Xiao-Yang Dong, Yong-Feng Cheng, Zhang-Long Yu, Qiang-Shuai Gu, Xin-Yuan Liu
The achiral ligand effect is utilized together with copper/phosphoric acid dual catalysis to achieve the first asymmetric radical oxytrifluoromethylation of alkene molecules with alcohols. In their Communication (DOI: 10.1002/anie.201702925), X.-Y. Liu et al. show that achiral pyridine acts as stabilizing ligands for transient copper intermediates in this novel transformation. The rationale may find broad applications in related asymmetric processes.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201704988

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