Current Opinion in Biotechnology
Current Opinion in Biotechnology
4 years ago

How to control cyclic nucleotide signaling by light

How to control cyclic nucleotide signaling by light
Optogenetics allows to non-invasively manipulate cellular functions with spatio-temporal precision by combining genetic engineering with the control of protein function by light. Since the discovery of channelrhodopsin has pioneered the field, the optogenetic toolkit has been ever expanding and allows now not only to control neuronal activity by light, but rather a multitude of other cellular functions. One important application that has been established in recent years is the light-dependent control of second messenger signaling. The optogenetic toolkit now allows to control cyclic nucleotide-dependent signaling by light in vitro and in vivo.

Publisher URL: www.sciencedirect.com/science

DOI: S0958166916302968

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