5 years ago

Synthetic RNA-based switches for mammalian gene expression control

Synthetic RNA-based switches for mammalian gene expression control
Synthetic ribonucleic acid (RNA)-based gene switches control RNA functions in a ligand-responsive manner. Key building blocks are aptamers that specifically bind to small molecules or protein ligands. Engineering approaches often combine rational design and high-throughput screening to identify optimal connection sites or sequences. In this report, we discuss basic principles and emerging design strategies for the engineering of RNA-based gene switches in mammalian cells. Their small size compared with those of transcriptional gene switches, together with advancements in design strategies and performance, may bring RNA-based switches to the forefront of biomedical and biotechnological applications.

Publisher URL: www.sciencedirect.com/science

DOI: S0958166916302907

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