European Journal of Organic Chemistry
European Journal of Organic Chemistry
5 years ago

Front Cover: Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones (Eur. J. Org. Chem. /2018)

Front Cover: Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones (Eur. J. Org. Chem. /2018)
Gedu Satyanarayana, Scuhand Basuli
The Front Cover shows a domino directing group free one-pot synthesis of 2-quinolinones from ortho-iodoacetanilides by palladium catalyzed direct acylation as the key step. The background represents a water source, signifying that the reaction is water tolerant and water in the TBHP helped to promote the reaction. Non-toxic aldehydes are used as acylating agents instead of toxic CO gas. In addition, one-pot formation of ortho-acylanilines via in situ base hydrolysis of ortho-iodoacetanilides is also presented. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds, for example, the syntheses of an HBV inhibitor and a key intermediate of Tipifarnib. More information can be found in the Full Paper by S. Basuli and G. Satyanarayana.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejoc.201800172

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