Journal of Vascular Surgery
Journal of Vascular Surgery
5 years ago

Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia.

Natalie A Drucker, S Keisin Wang, Andres Fajardo, Linden A Green, Raghu L Motaganahalli, Michael P Murphy
Currently, there are no accepted nonsurgical therapies that improve the delivery of blood-derived nutrients to patients with critical limb ischemia. Here, we describe the ongoing phase 1/2 Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial, which will provide crucial evidence of the safety profile of mesenchymal stromal cells (MSCs) and explore their therapeutic mechanisms in the setting of critical limb ischemia requiring below-knee amputation (BKA).

Publisher URL: http://doi.org/10.1016/j.jvs.2017.09.057

DOI: 10.1016/j.jvs.2017.09.057

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