Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Discovery and Enumeration of Organic-Chemical and Biomimetic Reaction Cycles within the Network of Chemistry

Discovery and Enumeration of Organic-Chemical and Biomimetic Reaction Cycles within the Network of Chemistry
Agnieszka Wołos, Sara Szymkuć, Michał D. Bajczyk, Bartosz A. Grzybowski, Piotr Dittwald
Analysis of the chemical-organic knowledge represented as a giant network reveals that it contains millions of reaction sequences closing into cycles. Without realizing it, independent chemists working at different times have jointly created examples of cyclic sequences that allow for the recovery of useful reagents and for the autoamplification of synthetically important molecules, those that mimic biological cycles, and those that can be operated one-pot. NOC-ing on heaven′s door: Big-data analysis of the network of organic chemistry (NOC), reveals that over many decades, chemists have created—unknowingly—millions of cyclic reaction sequences including those that recover valuable substrates, those that amplify useful chemicals, or those that mimic biological cycles. The image shows a special type of a cycle (the so-called clique) in which any member can be made from any other one in one step. Colors correspond to years in which a reaction was first reported.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201712052

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