European Journal of Organic Chemistry
European Journal of Organic Chemistry
5 years ago

Rhodium(III)-Catalyzed Regioselective Direct C4-Alkylation and C2-Annulation of Indoles: Straightforward Access to Indolopyridone

Aniruddha Biswas, Rajarshi Samanta
A straightforward Rh(III)-catalyzed strategy was developed for the site selective C4-alkylation and C2-annulation of indole using electronically variable diazo esters. The transformation was accomplished with the assist of oxime directing group at the C3 position of indole core with wide scope and functional group tolerance. The method directly provided indolopyridone core. The selectivity is triggered by the reactivity of the diazo coupling partner.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejoc.201701755

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