The HETE Is on FFAR1 and Pancreatic Islet Cells
It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate that glucose-induced 20-hydroxyeicosatetraenoic acid (20-HETE) amplifies insulin secretion through autocrine activation of FFAR1.
Publisher URL: http://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30055-X
DOI: 10.1016/j.cmet.2018.01.006
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