European Journal of Organic Chemistry
European Journal of Organic Chemistry
5 years ago

Acid-promoted Cascade Reaction of 4-Chloroquinolin-3-yl Carbamates with Amines: One-Pot Assembly of Imidazo[4,5-c]quinolin-2-ones

Hao Li, Wenwei Huang, Myunghoon Kim, Meghan Orr, Xiao Lu
An acid-promoted cascade reaction of 4-chloroquinolin-3-yl carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination with subsequent Suzuki coupling, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-c]quinolin-2-one derivatives.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/ejoc.201701772

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