5 years ago

Recombinant surface engineering to enhance and expand the potential of biologically produced nanoparticles: A review

Recombinant surface engineering to enhance and expand the potential of biologically produced nanoparticles: A review
Living organisms produce various membrane-enveloped organic and inorganic particles in the nanometer length scale. Among these particles, exosomes (a bilayer vesicle, extracellular organelle), poly-hydroxyalkanoates (monolayer, intracellular hydroxy-fatty acid granules), and magnetosomes (bilayer, intracellular iron particles) have been widely studied. In order to drive these particles toward biotechnological applications, surface engineering is crucial. Proteins exposed on the surfaces of these particles allow molecular engineers to display potent proteins or peptides of interest on the particles for specific functions. Upon surface protein presentation, such engineered particles can participate in diverse applications from protein purification to target clinical trials. This review article presents a summary of progress in the surface engineering of naturally produced particles in recent years. The concept underlying this surface engineering as well as the fundamentals of the synthesis and recovery of surface-engineered particles are also addressed in this review. The review concludes by highlighting surface engineering aspects that will facilitate further development of these nanoparticles for more applications.

Publisher URL: www.sciencedirect.com/science

DOI: S1359511316302458

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.