4 years ago

Optimal Contractile Forces for a Mesenchymal Engine

Dennis E. Discher, Lawrence J. Dooling

The cell and molecular mechanisms that cause a smooth epithelium to become topographically patterned during development are poorly understood. In a recent issue of Science, Shyer et al. (2017) show that myosin II contractility drives the smooth dermal mesenchyme into a pattern of surface bumps that triggers epithelial gene expression.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30633-0

DOI: 10.1016/j.devcel.2017.08.005

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