Nuclear Pore Complexes: A Scaffold Regulating Developmental Transcription?
Nuclear pore complexes (NPCs) have a conserved, but poorly understood, role in transcriptional regulation. Recently, in Developmental Cell, Raices et al. argued that tissue-specific nuclear pore proteins (Nups) act as scaffolds that recruit the transcription factor Mef2C to the NPC, promoting transcription of NPC-associated genes during muscle development.
Publisher URL: http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(17)30117-4
DOI: 10.1016/j.tcb.2017.07.002
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