Nanomedicine
Nanomedicine
5 years ago

Nanoimprinting of biomedical polymers reduces candidal physical adhesion.

Paul Reynolds, Gordon Ramage, Christopher J Nile, Ranjith Rajendran, Robert McKerlie, Nikolaj Gadegaard, Hasanain Alalwan
Management of fungal biofilms represents a significant challenge to healthcare. As a preventive approach, minimising adhesion between indwelling medical devices and microorganisms would be an important step forward. This study investigated the anti-fouling capacity of engineered nanoscale topographies to the pathogenic yeast Candida albicans. Highly ordered arrays of nano-pit topographies were shown to significantly reduce the physical adherence capacity of C. albicans. This study shows a potential of nanoscale patterns to inhibit and prevent pathogenic biofilm formation on biomedical substrates.

Publisher URL: http://doi.org/10.1016/j.nano.2018.01.011

DOI: 10.1016/j.nano.2018.01.011

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