Cardiovascular Research
Cardiovascular Research
5 years ago

Critical role of Phosphodiesterase 2A in mouse congenital heart defects.

Luigi Auletta, Daniele Gianfrilli, Elisabetta Vivarelli, Andrea Soricelli, Florencia Barrios, Andrea M Isidori, Fabio Naro, Marisa Cornacchione, Andrea Lenzi, Federica Barbagallo, Federica Campolo, Maria Rita Assenza, Manuela Pellegrini
Phosphodiesterase 2A, a cAMP-hydrolysing enzyme, is essential for mouse development, however the cause of Pde2A knockout embryonic lethality is unknown. To understand if Pde2A plays a role in cardiac development, hearts of Pde2A deficient embryos were analysed at different stage of development.

Publisher URL: http://doi.org/10.1093/cvr/cvy030

DOI: 10.1093/cvr/cvy030

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