BJOG: An International Journal of Obstetrics and Gynaecology
BJOG: An International Journal of Obstetrics and Gynaecology
5 years ago

The role of metformin and statins in the incidence of epithelial ovarian cancer in type 2 diabetes: a cohort and nested case-control study

Marianne Hinkula, Mikko Marttila, Reetta Arima, Pirjo Ilanne-Parikka, Martti Arffman, Elina Urpilainen, Ari Hautakoski, Reijo Sund, Esa Läärä, Ulla Puistola, Jenni Kangaskokko
Objective To obtain evidence of the effects of metformin and statins on the incidence of ovarian cancer in women with type 2 diabetes (T2D). Design A retrospective cohort study and nested case-control study. Setting The data were obtained from a diabetes database (FinDM) combining information from several nationwide registers. Population A cohort of 137 643 women over 40 years old and diagnosed with T2D during 1996 through 2011 in Finland. Methods In full cohort analysis Poisson regression was utilized to estimate the hazard ratios (HR) in relation to ever use of metformin, insulin, other oral antidiabetic medication or statins. In the nested case-control analysis 20 controls were matched to each case of ovarian cancer. Conditional logistic regression was used to estimate HRs in relation to medication use and cumulative use of different medications. The estimates were adjusted for age and duration of T2D. Main outcome measure. Incidence of ovarian cancer Results 303 women were diagnosed with ovarian cancer during the follow-up. Compared with other forms of oral antidiabetic medication, metformin (HR 1.02, 95% CI 0.72–1.45) was not found to be associated with the incidence of ovarian cancer. Neither was there evidence for statins to affect the incidence (HR 0.99, 95% CI 0.78–1.25). In nested case-control analysis the results were essentially similar. Conclusions No evidence of an association between the use of metformin or statins and the incidence of ovarian cancer in patients with T2D was found. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/1471-0528.15151

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