Investigating allosteric effects on the functional dynamics of [small beta]2-adrenergic ternary complexes with enhanced-sampling simulations

5 years ago

Investigating allosteric effects on the functional dynamics of [small beta]2-adrenergic ternary complexes with enhanced-sampling simulations

Giorgio Saladino, Francesco Luigi Gervasio, Timothy Clark, Noureldin Saleh

We propose an experimentally testable extended ternary complex model, where direction of the cooperative effect between ligand and intracellular binding partner (positive or negative) and its magnitude are predicted to be a characteristic of the ligand signaling bias.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/zOyk1F8vHWQ/C6SC04647A

DOI: 2017/SC/C6SC04647A

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