Organic Letters
Organic Letters
5 years ago

Anion Relay Enabled [3 + 3]-Annulation of Active Methylene Isocyanides and Ene-Yne-Ketones

Anion Relay Enabled [3 + 3]-Annulation of Active Methylene Isocyanides and Ene-Yne-Ketones
Mengru Hao, Lan Bao, Jinhuan Dong, Xinyi Zhou, Ni Li, Xianxiu Xu, Shenghua Ma, Zhongyan Hu
A new anion relay enabled [3 + 3]-annulation of active methylene isocyanides and conjugated ene-yne-ketones was developed for the efficient and straightforward synthesis of biologically valuable furo[3,2-c]pyridine derivatives. In this transformation, a sequential through-bond and through-space anion relay chemistry cascade is involved, which is initiated by an intermolecular Michael addition. Three new bonds and two rings are sequentially constructed from readily available acyclic precursors.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.8b00186

DOI: 10.1021/acs.orglett.8b00186

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