ACS Catalysis
ACS Catalysis
5 years ago

Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups

Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups
Eric Tan, Antonio M. Echavarren, M. Elena de Orbe, Ophélie Quinonero
We report the alkynylation of C(sp2)–H bonds with bromoalkynes (inverse-Sonogashira reaction) directed by synthetically useful ester, ketone, and ether groups under rhodium catalysis. Other less common directing groups such as amine, thioether, sulfoxide, sulfone, phenol ester, and carbamate are also suitable directing groups. Mechanistic studies indicate that the reaction proceeds by a turnover-limiting C–H activation step via an electrophilic-type substitution.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b04395

DOI: 10.1021/acscatal.7b04395

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