Ruthenium-catalyzed insertion of adjacent diol carbon atoms into C-C bonds: Entry to type II polyketides
Current catalytic processes involving carbon-carbon bond activation rely on -unsaturated coupling partners. Exploiting the concept of transfer hydrogenative coupling, we report a ruthenium(0)-catalyzed cycloaddition of benzocyclobutenones that functionalizes two adjacent saturated diol carbon-hydrogen bonds. These regio- and diastereoselective processes enable convergent construction of type II polyketide substructures.
Publisher URL: http://science.sciencemag.org/cgi/content/short/357/6353/779
DOI: 10.1126/science.aao0453
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