Immunosuppressant prescription pattern and trend in kidney transplantation: A multicenter study in Korea

by Ji-Yeun Chang, Jihyun Yu, Byung Ha Chung, Jaeseok Yang, Sung-Joo Kim, Chan-Duck Kim, Sang-Ho Lee, Jong Soo Lee, Joong Kyung Kim, Cheol Woong Jung, Chang Kwon Oh, Chul Woo Yang

The actual prescription pattern of immunosuppressive agents in kidney transplantation is unclear.

We investigated the pattern and trend of immunosuppressive treatment for kidney transplant patients in South Korea. A total of 636 patients at nine transplant centers were enrolled and followed for one year. We reviewed medical records and evaluated induction therapy, as well as the changing pattern and cause of maintenance therapy.

Most patients (n = 621, 97.6%) received induction therapy often comprising basiliximab (n = 542, 85.2%). The triple therapy including calcineurin inhibitor, mycophenolic acid, and steroids was the major initial maintenance immunosuppression (n = 518, 81.4%), but its proportion decreased by 14% (81.4% to 67.5%) after 1 year. Almost 40% of patients changed immunosuppressive regimen during the 1-year follow-up, most often at an early period (60.2% within the first 4 months). The primary reason for the change was gastrointestinal discomfort (n = 113, 29.8%), followed by infection (112, 29.6%). The most common changing pattern was mycophenolic acid withdrawal (n = 155, 39.1%).

The initial immunosuppressive regimen is prone to change within the first year of kidney transplantation. Further studies are needed to evaluate the benefits and risks in patients who changed immunosuppressants.