3 years ago

The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants

Peter Nürnberg, Egbert Herting, Wolfgang Göpel, Christian M. Karsten, Christoph Härtel, for the German Neonatal Network (GNN), Alexander Humberg, Michael Preuss, Lena Schreiter, Julia Figge, Julia Pagel, Jan Rupp, Annika Hartz

by Annika Hartz, Julia Pagel, Alexander Humberg, Michael Preuss, Lena Schreiter, Jan Rupp, Julia Figge, Christian M. Karsten, Peter Nürnberg, Egbert Herting, Wolfgang Göpel, Christoph Härtel, for the German Neonatal Network (GNN)

Objectives

Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).

Methods

We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.

Results

We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.

Conclusions

In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.

Publisher URL: http://journals.plos.org/plosone/article

DOI: 10.1371/journal.pone.0178032

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