Inorganic Chemistry
Inorganic Chemistry
5 years ago

Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress

Prion Peptides Are Extremely Sensitive to Copper Induced Oxidative Stress
Giuseppe Di Natale, Simone Dell’Acqua, Luigi Casella, Chiara Bacchella, Enrico Rizzarelli, Stefania Nicolis, Enrico Monzani
Copper bound to prion peptides at the high affinity site adjacent to the octarepeats exhibits marked catalytic activity toward dopamine and 4-methylcatechol. Cu redox cycling and reactive quinones produce an extensive array of peptide oxidation and modification, yielding catechol adducts at the histidine binding ligands. Prion peptides appear to be much more sensitive to oxidative stress than β-amyloid and α-synuclein.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01757

DOI: 10.1021/acs.inorgchem.7b01757

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