3 years ago

Monofunctional BODIPY-Appended Imidazoplatin for Cellular Imaging and Mitochondria-Targeted Photocytotoxicity

Monofunctional BODIPY-Appended Imidazoplatin for Cellular Imaging and Mitochondria-Targeted Photocytotoxicity
Aditya Garai, Md Kausar Raza, Akhil R. Chakravarty, Srishti Gautam, Koushambi Mitra, Paturu Kondaiah
Monofunctional imidazoplatin complexes having pendant photoactive BODIPY moieties as mitochondria-localizing anticancer agents are prepared and studied. They exhibit remarkable apoptotic photocytotoxicity in visible light (400−700 nm) in skin keratinocyte HaCaT and breast cancer MCF-7 cells by generating singlet oxygen as the reactive species, while being nontoxic in dark. The emisssive noniodo BODIPY complex showed mitochondrial localization, while its diiodo analogue displayed excellent PDT activity. 9-Ethylguanine addition showed monoadduct formation with replacement of one ammine ligand.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01346

DOI: 10.1021/acs.inorgchem.7b01346

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