Inorganic Chemistry
Inorganic Chemistry
4 years ago

Monofunctional BODIPY-Appended Imidazoplatin for Cellular Imaging and Mitochondria-Targeted Photocytotoxicity

Monofunctional BODIPY-Appended Imidazoplatin for Cellular Imaging and Mitochondria-Targeted Photocytotoxicity
Aditya Garai, Md Kausar Raza, Akhil R. Chakravarty, Srishti Gautam, Koushambi Mitra, Paturu Kondaiah
Monofunctional imidazoplatin complexes having pendant photoactive BODIPY moieties as mitochondria-localizing anticancer agents are prepared and studied. They exhibit remarkable apoptotic photocytotoxicity in visible light (400−700 nm) in skin keratinocyte HaCaT and breast cancer MCF-7 cells by generating singlet oxygen as the reactive species, while being nontoxic in dark. The emisssive noniodo BODIPY complex showed mitochondrial localization, while its diiodo analogue displayed excellent PDT activity. 9-Ethylguanine addition showed monoadduct formation with replacement of one ammine ligand.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01346

DOI: 10.1021/acs.inorgchem.7b01346

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.