3 years ago

Mueller Matrix Fluorescence Spectroscopy for Probing Self-Assembled Peptide-Based Hybrid Supramolecular Structure and Orientation

Mueller Matrix Fluorescence Spectroscopy for Probing Self-Assembled Peptide-Based Hybrid Supramolecular Structure and Orientation
Rajib Dey, Debasish Haldar, Sudipta Saha, Nirmalya Ghosh, Krishnendu Maji
Probing the assembly mechanism, orientation, shape, and structure function relationship of hybrid supramolecular materials is an outstanding challenge. In this regard, we have presented a novel method based on fluorescence spectroscopic Mueller matrix measurements and inverse analysis which can probe and quantify exclusive information on the molecular organization and orientation via a set of newly defined fluorescence anisotropy parameters, namely, fluorescence diattenuation and polarizance. A new dipeptide motif Boc-Xaa-Met-OMe (Xaa = Val/Leu) containing leucine, valine, and methionine forms a kink like structure and self-associates to form a twisted sheet like structure by multiple intermolecular N–H···O hydrogen bonds and finally grown to form supramolecular nanotubes having a diameter ca. 10 Å. Thus, the methionine sulfurs of peptide molecules are arranged helically along the tubes, work as a hot spot, and help to stabilize the electron deficient paint TB-NDI around the tube. The fluorescence Mueller matrix polarimetry and inverse analysis offers insight on the molecular organization and orientation of the achiral fluorescent dye molecules around the supramolecular nanotube from the chiral dipeptide. This method is promising for characterization of complex hybrid materials.

Publisher URL: http://dx.doi.org/10.1021/acs.jpcc.7b06725

DOI: 10.1021/acs.jpcc.7b06725

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.