3 years ago

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites
Alan F. Cowman, Christopher J. Tonkin, Manoj T. Duraisingh, Wai-Hong Tham

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.

Publisher URL: http://www.cell.com/cell-host-microbe/fulltext/S1931-3128(17)30286-X

DOI: 10.1016/j.chom.2017.07.003

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