British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology
5 years ago

Acenocoumarol As An Alternative Anticoagulant In A Patient With Warfarin Related Nephropathy

Satish Haridasan, Sandhiya Selvarajan, Bheemanathi Hanuman Srinivas, Alphienes Stanley Xavier, Hemachandren Munuswamy, Sapan Kumar Behera
Adverse event Warfarin related nephropathy Drug implicated Warfarin The patient A 31 year old female, managed with warfarin for rheumatic heart disease with atrial fibrillation. Evidence that links the drug to the event There were no alternative causes of nephropathy that could have caused the adverse event in this patient. Management Shifting the drug from warfarin to acenocoumarol Mechanism, if known Difference in renal elimination between warfarin and acenocoumarol Implication for therapy Clinicians should be aware of this rare adverse effect of warfarin and acenocoumarol can be considered as an alternative therapy for this condition. Hypotheses to be tested Further prospectively designed studies are needed to consider acenocoumarol as an alternative therapy in warfarin related nephropathy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bcp.13541

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