Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Direct Palladium-Catalyzed β-Arylation of Lactams

Feipeng Liu, Ming Chen, Guangbin Dong
A direct and catalytic method is reported here for β-arylation of N-protected lactams with simple aryl iodides. The transformation is enabled by merging soft enolization of lactams, Pd-catalyzed desaturation, Ar-X bond activation and aryl conjugate addition. The reaction is operated under mild conditions, scalable and chemoselective. Application of this method to concise syntheses of pharmaceutically relevant compounds is demonstrated.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201800958

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