European Heart Journal
European Heart Journal
5 years ago

Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors.

Mathilde Lemitre, Yeranuhi Hovhannisyan, Anaïs Kervadec, Albert Hagège, Camille Brunaud, Laetitia Pidial, Angéline Duché, Nicolas Cagnard, Nisa K E Renault, Marc P Renault, Alexandra T Bourdillon, Marie-Cécile Perier, Nadia El Harane, Jeanne Gauthier, Léa Thiébault, Alexandre R Colas, Solenne Paiva, Bruna Lima Correa, Philippe Menasché, Hany J Neametalla, Valérie Bellamy, Jean-Sébastien Silvestre, Onnik Agbulut
We have shown that extracellular vesicles (EVs) secreted by embryonic stem cell-derived cardiovascular progenitor cells (Pg) recapitulate the therapeutic effects of their parent cells in a mouse model of chronic heart failure (CHF). Our objectives are to investigate whether EV released by more readily available cell sources are therapeutic, whether their effectiveness is influenced by the differentiation state of the secreting cell, and through which mechanisms they act.

Publisher URL: http://doi.org/10.1093/eurheartj/ehy012

DOI: 10.1093/eurheartj/ehy012

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