Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.

American Journal of Respiratory and Critical Care Medicine

5 years ago

Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.

A John Simpson, Stephen P Cummings, Andrew Nelson, James Garnett, Jason Powell, Jon Scott, Faye A H Cooles, Bernard Verdon, Janet A Wilson, Stephen E Wright, Jeffrey Pearson, John D Perry, Michael W Mather, Chris Ward, Marie-Hélène Ruchaud-Sparagano, Kasim Jiwa

Aspiration of infective subglottic secretions causes ventilator-associated pneumonia (VAP) in mechanically ventilated patients. Mechanisms underlying subglottic colonization in critical illness have not been defined, limiting strategies for targeted prevention of VAP.

Publisher URL: http://doi.org/10.1164/rccm.201709-1819OC

DOI: 10.1164/rccm.201709-1819OC

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