Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry
5 years ago

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton

Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton
The estrogen receptor (ER), a member of the nuclear receptor (NR) family, is involved in the regulation of physiological effects such as reproduction and bone homeostasis. Approximately 70% of human breast cancers are hormone-dependent and ERα-positive, and, thus, ER antagonists are broadly used in breast cancer therapy. We herein designed and synthesized a set of ER antagonists with a 4-heterocycle-4-phenylheptane skeleton.

Publisher URL: www.sciencedirect.com/science

DOI: S0968089618300609

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