5 years ago

Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes

Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes
Carlos Sanchez-Cano, Peter J. Sadler, Andrea F. Lopez-Clavijo, Christopher A. Wootton, Evyenia Shaili, Peter B. O'Connor, Mark P. Barrow
Octahedral anticancer platinum(IV) complexes such as trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2] (1) can target peptides (and proteins) by sequence-dependent platination and radical mechanisms when activated by UVA or visible light; the specific products are highly dependent on their amino acid composition of the peptide.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/q2kd63mYOvs/C7SC05135B

DOI: 2018/SC/C7SC05135B

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