Pharmacological strategies in heart failure with preserved ejection fraction: time for an individualised treatment strategy?
Heart failure (with preserved ejection fraction (HFpEF) is a major global health issue. Indeed, with the ageing of the population, its prevalence is growing, affecting between 1.1% and 5.5% of the global population, and accounting for 50% of HF cases.
HFpEF is a complex clinical syndrome with a large variety of phenotypes. Its definition is not simple, with no gold standard, making the diagnosis sometimes challenging for the clinician, and explaining therefore the heterogeneity of patients included in the different studies. HFpEF is characterised by symptoms and signs of HF associated with a normal or nearly normal left ventricular ejection fraction. The definition of ‘preserved’ ejection fraction (EF) in previous clinical trials was not homogeneous, with cut-off values varying from 40% to 50%. The latest European Society of Cardiology (ESC) guidelines have chosen a cut-off value of ≥50% and have created a new category called...
Publisher URL: http://heart.bmj.com/cgi/content/short/104/5/365
DOI: 10.1136/heartjnl-2017-312119
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