4 years ago

Early Detection Of Hiv Infection And Of Asymptomatic Sexually Transmitted Infections Among Men Who Have Sex With Men

To provide data on incidence of early diagnosis of HIV infections and define prevalence and incidence of asymptomatic STI in MSM. Methods Prospective cohort study of HIV-uninfected MSM at high-risk for HIV-infection. Participants were selected through a risk-assessment questionnaire, and screened for HIV-infection (quarterly) and for other STIs (yearly): syphilis, hepatitis A, B and C (serology); C. trachomatis and N. gonorrhoeae in penis and rectum and Human Papillomavirus in anus and mouth (PCR). Results Between November 2009 and October 2012, 258 HIV-uninfected MSM at high-risk for HIV-infection were included and followed-up during [median (IQR)] 2 (1.4, 2.5) years. Nineteen acute HIV-infections were diagnosed (incidence: 3.9 per 100 person-years). Prevalence of STIs at baseline was: syphilis 8.4% (95%CI: 5.4–12.7); HCV 2.0% (95%CI: 0.7-4.8); C. trachomatis in penis 3.2% (95%CI:1.5-6.5), in rectum 6.5% (95%CI:3.9-10.5); N. gonorrhoeae in penis 2.0% (95%CI:0.8-5.0), in rectum 6.1% (95%CI:3.6-10.1); HPV in anal canal 75.7% (95%CI:68.8-81.5), in mouth 3.8% (95%CI:1.8-7.7). Conclusions The implementation of the Check-ear-project in a MSM community centre allowed for the identification of early HIV-infections and asymptomatic STI among MSM. The high incidence of HIV infections and the high prevalence of STIs, strongly supports the recommendation of periodical screenings among sexually active MSM.

Publisher URL: www.sciencedirect.com/science

DOI: S1198743X17304585

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