Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Palladium(II)-Catalyzed Deacylative Allylic C–H Alkylation

Palladium(II)-Catalyzed Deacylative Allylic C–H Alkylation
Xiao-Le Zhou, Lei Ren, Pu-Sheng Wang
The first deacylative allylic C–H alkylation has been established by employing the palladium-catalyzed allylic C–H activation and decarboxylative nucleophile generation. A wide scope of nucleophiles are tolerated and densely functionalized alkylation products turn out to be furnished in moderate to good yield. More importantly, this strategy provides an alternative method for the allylic C–H alkylation with less stabilized carbon nucleophiles, and can be further expanded to the synthesis of unconjugated enynes.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00919

DOI: 10.1021/acs.joc.7b00919

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