Crystal Growth & Design
Crystal Growth & Design
5 years ago

Nucleation and Growth Kinetics for Combined Cooling and Antisolvent Crystallization in a Mixed-Suspension, Mixed-Product Removal System: Estimating Solvent Dependency

Nucleation and Growth Kinetics for Combined Cooling and Antisolvent Crystallization in a Mixed-Suspension, Mixed-Product Removal System: Estimating Solvent Dependency
Richard D. Braatz, Jennifer M. Schall, Jasdeep S. Mandur, Allan S. Myerson
Solvent- and temperature-dependent kinetic parameters were regressed simultaneously for continuous, mixed-suspension, mixed-product removal (MSMPR) crystallization. Both growth and nucleation kinetic parameters were demonstrated to be strong functions of solvent composition, while only growth was a strong function of temperature for the studied active pharmaceutical ingredients/solvent/antisolvent system. A method for using a minimum of six steady-state MSMPR experiments to regress kinetics is also presented, enabling rapid MSMPR cascade design and optimization for antisolvent crystallization processes.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b01528

DOI: 10.1021/acs.cgd.7b01528

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