4 years ago

Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide

Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide
Weizhun Yang, Zeren Zhang, Xuefei Huang, Sherif Ramadan
Syndecan-1 chondroitin sulfate glycopeptide was synthesized for the first time using the cassette approach. The sequence of glycosylation to form the octasaccharide serine cassette was critical. The glycopeptide was successfully assembled via a 2+ (3 + 3) glycosylation strategy followed by peptide chain elongation.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02271

DOI: 10.1021/acs.orglett.7b02271

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