5 years ago

Nitazoxanide is active against <i>Mycobacterium leprae</i>

Mai Ann Bailey, Thomas P. Gillis, Ramanuj Lahiri, Hana Na, Tanya Parish, Malcolm S. Duthie

by Mai Ann Bailey, Hana Na, Malcolm S. Duthie, Thomas P. Gillis, Ramanuj Lahiri, Tanya Parish

Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M. leprae. Further, gavage of M. leprae-infected mice with NTZ at 25mg/kg provided anti-mycobacterial activity equivalent to rifampicin (RIF) at 10 mg/kg. This suggests that NTZ could be considered for leprosy treatment.

Publisher URL: http://journals.plos.org/plosone/article

DOI: 10.1371/journal.pone.0184107

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