Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Phosphoribosyl Pyrophosphate: A Molecular Vestige of the Origin of Life on Minerals

Phosphoribosyl Pyrophosphate: A Molecular Vestige of the Origin of Life on Minerals
Marie-Christine Maurel, Maguy Jaber, Jean-Francois Lambert, Mariame Akouche, Thomas Georgelin
In this contribution, we report the formation under prebiotic conditions of phosphoribosyl pyrophosphate (PRPP) as a molecular precursor in the one-pot synthesis of a canonical nucleotide, namely adenosine monophosphate (AMP) from its building blocks (KH2PO4 or Pi, adenine, and d-ribose), on a fumed silica surface. The on-the-rocks approach has been successfully applied to the simultaneous phosphorylation and glycosylation of ribose. The one-pot formation mechanism of AMP involves a two-step pathway via an activated intermediate, namely PRPP, obtained by multiple ribose phosphorylations upon mild thermal activation. AMPing up prebiotic synthesis: The formation of phosphoribosyl pyrophosphate (PRPP) under prebiotic conditions is reported. PRPP was further used as a molecular intermediate in the one-pot synthesis of a canonical nucleotide, namely adenosine monophosphate (AMP) from its building blocks (KH2PO4, adenine, and d-ribose), on a fumed silica surface.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702633

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.