Crystal Growth & Design
Crystal Growth & Design
5 years ago

Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis

Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis
Calum J. Drummond, Alexandru Zabara, Ehud M. Landau, Thomas G. Meikle, Charlotte E. Conn, Thomas S. Peat, Raphael Trenker, Frances Separovic, Matthew E. Call, Melissa J. Call, Shenggen Yao, Janet Newman
A detailed, systematic investigation into the factors contributing to successful crystallization of membrane proteins in meso. We find compelling evidence for the role of the chemical structure of the lipid, the physical properties of the mesophase, and the translational diffusion of the encapsulated membrane protein itself.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b00519

DOI: 10.1021/acs.cgd.7b00519

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