Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Direct Cyclization of Tertiary Arylamines with Iodonium Ylides

Lei Feng, Shuya Liu, Liang Zhang, Yao Wang, Zhiguo Zhao, Yongrui Luo
Described herein is a direct cyclization of simple tertiary arylamines with iodonium ylides leading to a broad range of N-heterocycles. Completely different from known reactivity of iodonium ylides, an exceptional finding reported herein is that iodonium ylide is capable of cleaving a C(sp3)-H bond and accepting two hydrogen atoms of tertiary arylamine, thus inducing a novel cyclization process. This transformation can proceed without assistance of a transition metal catalyst while eliminating the need for premodification of amines or using additional initiator/oxidant.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201800389

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.