5 years ago

Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange

Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange
Floris P. J. T. Rutjes, Meike Emondts, Roman V. Shchepin, Angus W. J. Logan, Bernhard Blümich, Johannes F. P. Colell, Steven J. Malcolmson, Gerardo X. Ortiz, Martin C. Feiters, Junu Bae, Kun Shen, Thomas Theis, Qiu Wang, Eduard Y. Chekmenev, Warren S. Warren, Peter Spannring
Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived 1H-polarization, and relatively limited substrate scope. Here we use a water-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei). This strategy works in pure H2O or D2O solutions, on substrates that could not be hyperpolarized in traditional 1H-SABRE experiments, and we record 15N T1 relaxation times of up to 2 min.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b00569

DOI: 10.1021/jacs.7b00569

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