Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Synthesis and Applications of Boronate Affinity Materials: From Class Selectivity to Biomimetic Specificity

Synthesis and Applications of Boronate Affinity Materials: From Class Selectivity to Biomimetic Specificity
Hui He, Zhen Liu
Due to the complexity of biological systems and samples, specific capture and targeting of certain biomolecules is critical in much biological research and many applications. cis-Diol-containing biomolecules, a large family of important compounds including glycoproteins, saccharides, nucleosides, nucleotides, and so on, play essential roles in biological systems. As boronic acids can reversibly bind with cis-diols, boronate affinity materials (BAMs) have gained increasing attention in recent years. However, real-world applications of BAMs are often severely hampered by three bottleneck issues, including nonbiocompatible binding pH, weak affinity, and difficulty in selectivity manipulation. Therefore, solutions to these issues and knowledge about the factors that influence the binding properties are of significant importance.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00179

DOI: 10.1021/acs.accounts.7b00179

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