European Journal of Immunology
European Journal of Immunology
5 years ago

Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration

Joerg Renkawitz, Michael Sixt, Hans Häcker, Ingrid Vries, Robert Hauschild, Alexander Leithner
Dendritic cells (DCs) are sentinels of the adaptive immune system that reside in peripheral organs of mammals. Upon pathogen encounter, they undergo maturation and up-regulate the chemokine receptor CCR7 that guides them along gradients of its chemokine ligands CCL19 and 21 to the next draining lymph node. There, DCs present peripherally acquired antigen to naïve T cells, thereby triggering adaptive immunity. This article is protected by copyright. All rights reserved

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/eji.201747358

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